What Is Ozone Therapy : Ozone (O3) has great oxidizing activity as a soluble gas. When in contact with biological fluids, it forms reactive oxygen species as well as lipid oxidation products. Both of these products react with white blood cells initiating the formation of proteins, cytokines, and red blood cells which increases the tissue oxygen supply. O3 is used to treat many cases regarding the muscles, tendons, and joints. There is a common theme among many literature reports that O3 reduces local pain which favors the mobility lost during the painful state and recovery of joint function.