Ozone therapy is highly effective in reliving both acute and chronic back pain. It is safe, convenient, and inexpensive. Ozone has a short half-life of approximately 1 hour at room temperature. It has been used in relieving pain in degenerative disc disease and is a superior option than steroid use. It can be administered as a first line treatment. Both the intradiscal and intramuscular injection of oxygen-ozone are successful approaches.